硕士生导师

研究方向

1. 病毒感染与复制机制
2. 抗病毒药物及疫苗研发

 

工作经历

2019/02 - 至今    中山大学公共卫生学院（深圳），副教授
2015/07-2019/01   浙江理工大学，讲师
2015/07-2017/09   美国宾州州立大学医学院，博士后

 

教育经历

2010/09-2015/06   复旦大学，病原生物学，理学博士
2006/09-2010/06   南京农业大学，生物技术（国家生命科学与技术基地班），理学学士

 

主要承担课题及人才项目

1. 国家自然科学基金，面上项目，2025-2028，在研，项目负责人

2. 国家自然科学基金，青年基金项目，2021-2023，结题，项目负责人

3. 深圳市科技创新委员会，高校稳定支持面上项目，2022-2025，在研，项目负责人

4. 国家重点研发计划，2021-2024，在研，课题骨干

5. 深圳市高层次人才团队项目，2021-2026，在研，核心成员

6. 深圳市科技创新委员会，技术攻关重点项目，2020-2023，结题，核心成员

7. 中山大学青年教师培育项目，2019-2021，结题，项目负责人

8. 浙江省自然科学基金青年基金项目，2019-2021，结题，项目负责人


发表论文

  1. Sun J#, Lu S#, Xiao J, Xu N, Li Y, Xu J, Deng M, Xuanyuan H, Zhang Y, Wu F, Jin W*, Liu K*. Inhibition of SARS-CoV-2 replication by self-assembled siRNA nanoparticles targeting multiple highly conserved viral sequences. Viruses 2024, 16:1072.
  2. Chen Z#, Yuan Y#, Yang D, Luo M, Liang Q, LiZ, Lu S, Sun J, Deng M, Liu M, Liang Z*, Liu K*. Antiviral activities of Polygonum perfoliatum L. extract and related phenolic acid constituents against hepatitis B virus. Journal of Medical Virology 2022, 94(12):5987-5999.
  3. Luo M#, Chen Z#, Liu M, Liang Q, Han R, Liang Z, Ye Z*, Liu K*. Inhibitory activities of Ranunculus japonicus Thunb. ethanol extract against hepatitis B virus. Journal of Medical Virology 2022, 94(6):2727-2735.
  4. Xi J, Cui X, Liu K, Liu H, Wang J, Hu J*. Region-Specific Hepatitis B Virus Genome Exposure from Nucleocapsid Modulated by Capsid Linker Sequence and Inhibitor: Implications for Uncoating. Journal of Virology 2022, 96(8):e0039922.
  5. Li Z#, Wang W#, Xiao Y#, Du S, Chen Z, Li B, Zhou Z, Liu K*, Gao F*, Sun L*. Discovery of a small-molecule inhibitor targeting the ovarian tumor domain of a novel Tamdy orthonairoviruse associated with human febrile illness. Journal of Medical Virology 2022, 94(12):5954-5964.
  6. Zhao Y, Zhu Z, Xiao Q, Li Z, Jia X, Hu W, Liu K*, Lu S*. Urinary neonicotinoid insecticides in children from South China: Concentrations, profiles and influencing factors. Chemosphere 2021: 132937.
  7. Liu K*, Hu J. Secretion of Empty or Complete Hepatitis B Virions: Envelopment of Empty Capsids vs. Mature Nucleocapsids. Future Virology 2019, 14(2), 95-105.
  8. Liu K, Luckenbaugh L, Ning X, Xi J, Hu J*. Multiple Roles of Core Protein Linker in Hepatitis B Virus Replication. PLoS Pathogens 2018, 14(5): e1007085.
  9. Zhang X, Yu Y, Cen Y, Yang D, Qi Z, Hou Z, Han S, Cai Z, Liu K*. Bivariate Correlation Analysis of the Chemometric Profiles of Chinese Wild Salvia miltiorrhiza Based on UPLC-Qqq-MS and Antioxidant Activities. Molecules 2018, 23(3).
  10. Liu K, Hu J*. Host-regulated Hepatitis B Virus Capsid Assembly in a Mammalian Cell-free System. Bio-protocol 2018, 8(8): e2813. DOI: 10.21769/BioProtoc.2813.
  11. Ning X, Luckenbaugh L, Liu K, Bruss V, Sureau C, Hu J*. Common and Distinct Capsid and Surface Protein Requirements for Secretion of Complete and Genome-free Hepatitis B Virions. Journal of Virology 2018, doi:10.1128/JVI.00272-18.
  12. Hu J*, Liu K. Complete and Incomplete Hepatitis B Virus Particles: Formation, Function, and Application. Viruses 2017, 9(3), 56.
  13. Ning X, Basagoudanavar S, Liu K, Luckenbaugh L, Wei D, Wang C, Wei B, Zhao Y, Yan T, Delaney W, Hu J*. Capsid Phosphorylation State and Hepadnavirus Virion Secretion. Journal of Virology 2017, 91(9), e00092-17.
  14. Ludgate L#, Liu K#, Luckenbaugh L, Streck N, Eng S, Voitenleitner C, Delaney W, Hu J*. Cell-free Hepatitis B Virus Capsid Assembly Dependent on Core Protein C-Terminal Domain and Regulated by Phosphorylation. Journal of Virology 2016, 90(12): 5830–5844.
  15. Liu K, Ludgate L, Yuan Z, Hu J*. Regulation of Multiple Stages of Hepadnavirus Replication by the Carboxyl-Terminal Domain of Viral Core Protein in trans. Journal of Virology 2015, 89(5): 2918-2930
  16. Cui X, Clark D, Liu K, Xu X, Guo J, Hu J*. Viral DNA-dependent Induction of Innate Immune Response to Hepatitis B Virus in Immortalized Mouse Hepatocytes. Journal of Virology 2015, 90(1): 486-496.
  17. Chen J, Wu M, Liu K, Zhang W, Li Y, Zhou X, Bai L, Yuan Z*. New insights into hepatitis B virus biology and implications for novel antiviral strategies. Natl Sci Rev 2015, 2 (3): 296-313.
  18. Li J, Liu K, Liu Y, Xu Y, Zhang F, Yang H, Liu J, Pan T, Chen J, Wu M, Zhou X, Yuan Z*. Exosomes mediate the cell-to-cell transmission of IFN-alpha-induced antiviral activity. Nature Immunology 2013, 14(8): 793-803.
  19. Li J, Liu Y, Wang Z, Liu K, Wang Y, Liu J, Ding H, Yuan Z*. Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment. Journal of Virology 2011, 85(13): 6319-6333.


招生信息

       接收本科生2-3人/年进行科研培训，招收硕士生2人左右/年。欢迎对病毒感染与复制机制、抗病毒药物及疫苗研发等方向感兴趣的研究生和本科生加入！
联系人：刘宽程；联系方式：liukuanc@mail.sysu.edu.cn