博士生导师
研究方向
1. 病毒与宿主相互作用
2. 疫苗研发
工作经历
2019/05 - 至今 中山大学公共卫生学院（深圳），副教授
2017/10-2019/04 德克萨斯大学免疫&微生物系，研究专员
2013/09-2017/09 德克萨斯大学免疫&微生物系，博士后
教育经历
2008/09-2013/07 中国科学院武汉病毒所，生物化学与分子生物，理学博士
2004/09-2008/07 河南师范大学，生命科学，理学学士
人才项目
1. 国家自然国学基金委，面上基金项目，2023-01至2026-12，主持
2. 国家自然科学基金委，青年科学基金项目， 2021-01至2023-12，24.00万元，结题，主持
3. 深圳市科技创新委员会，自由探索面上项目，2020-04至2023-05，主持
4. 深圳市南山区引进高层次医学团队项目(三名工程)，2022.06-2027.05，子课题负责人
5.深圳市高层次人才团队项目(青年孔雀团队)，2021.05-2026.04，核心成员
6.国家重点研发专项，2021.04-2024.03，骨干人员
7.国家重点研发专项，2021.12至2024.11，骨干人员
8.中央军委后勤保障部项目，2021.01-2023.12，骨干人员
9.广州市科技计划项目(202008040004)，已结题，参与
10.广东省重点领域研发计划项目(2020B111107001)，已结题，参与
发表论文
1.Shengze Zhang#, Nina Li#, Shu Wu, Ting Xie, Qiqi Chen, Jiani Wu, Shike Zeng, Lin Zhu, Shaohui Bai, Haolu Zha, Weijian Tian, Nan Wu, Xuan Zou, Shisong Fang, Chuming Luo, Mang Shi, Caijun Sun, Yuelong Shu and Huanle Luo*.c-FLIP facilitates ZIKV infection by mediating caspase-8/3-dependent apoptosis. PLoS Pathogens. 2024. Accepted.
2.Shengze Zhang#, Chuming Luo#, Qiqi Chen, Nina Li, Xinzhong Liao, Jiani Wu, Haolu Zha, Ting Xie, Shaohui Bai, Weijian Tian, Lin Zhu, Xuan Zou, Shisong Fang, Caijun Sun, Ying Jiang, Jianhui Yuan, Yuelong Shu*, Nan Wu*, and Huanle Luo*. ZIKV Induces P62-Mediated Autophagic Degradation of TRAF6 through TRAF6-NS1 Interaction. iScience. 2024. Accepted.
3.Qiqi Chen#, Nina Li#, Shike Zeng#, Shu Wu , Xin Luo，Shengze Zhang, Lin Zhu, Jiani Wu, Ting Xie, Shaohui Bai, Hao Zhang, Zhiyuan Jiang, Shaoli Lin, Nan Wu, Ying Jiang, Shisong Fang, Xin Wang, Yuelong Shu and Huanle Luo*. ZIKV infection differentially affects the transcriptional profiles in HTR8 and U251 cells. Virus Res.2023 Sep;334:199166.
4.Jiani Wu#, Wei Liu#, Lin Zhu#, Nina Li#, Gengyan Luo, Ming Gu, Minwu Peng, Shike Zeng, Shu Wu, Shengze Zhang, Qiqi Chen, Meiqi Cai, Wei Cao, Ying Jiang, Chuming Luo, Dechao Tian, Mang Shi, Yuelong Shu*, Guohui Chang* and Huanle Luo*. Dysbiosis of oropharyngeal microbiome and antibiotic resistance in hospitalized COVID-19 patients. J Med Virol. 2023;95(4):e28727.
5.Nina Li#, XueYun Li#, Jiani Wu, Shengze Zhang, Lin Zhu, Qiqi Chen, Ying Fan, Zhengyu Wu, Sidian Xie, Qi Chen, Ning Wang, Nan Wu, Chuming Luo, Yuelong Shu* and Huanle Luo*. Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in children. Front Immunol. 2022, 1042406.
6.Qian Xie #, Xinzhong Liao #, Bi Huang, Liangliang Wang, Guancheng Liao, Chuming Luo, Simin Wen, Shisong Fang, Huanle Luo* and Yuelong Shu*. The truncated IFITM3 facilitates the humoral immune response in inactivated influenza vaccine-vaccinated mice via interaction with CD81.Emerg Microbes Infect. 2023; 12(2):2246599. (期刊论文)
7.Tingting Jia#, Yuankai Wu#, Guancheng Liao#, Yuxuan Lei, Zhengyu Wu, Fangji Yang, Jiamin Chen, Qian Xie, Chuming Luo, Yutian Chong*, Huanle Luo* and Yuelong Shu*. Stable and durable antibody responses in SARS-recovered donors vaccinated with inactivated SARS-CoV-2 vaccine. J Med Virol. 2023;95(3):e28662.
8.Xiao Sun, Yingzhi Liu, Ziheng Huang, Wenye Xu, Wei Hu, Lina Yi, Zhe Liu, Hung Chan, Judeng Zeng, Xiaodong Liu, Huarong Chen, Jun Yu, Francis Ka Leung Chan, Siew Chien Ng, Sunny Hei Wong, Maggie Haitian Wang, Tony Gin, Gavin Matthew Joynt, David Shu Cheong Hui, Xuan Zou, Yuelong Shu, Christopher Hon Ki Cheng, Shisong Fang*, Huanle Luo*, Jing Lu*, Matthew Tak Vai Chan*, Lin Zhang* and William Ka Kei Wu*. SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1. Cell Death Differ. 2022 Jun;29(6):1240-1254.
9.Wenye Xu#, Yingzhi Liu#, Xuan Zou#, Huanle Luo#, Weihua Wu, Junjie Xia, Matthew T. V. Chan*, Shisong Fang*, Yuelong Shu*, William K. K. Wu* and Lin Zhang*. Hypozincemia in COVID-19 Patients Correlates With Stronger Antibody Response. Front Immunol. 2022 Jan 4;12:785599.
10.Huanle Luo#, Tingting Jia#, Jiamin Chen, Shike Zeng, Zengzhao Qiu, Shu Wu, Xu Li, Yuxuan Lei, Xin Wang, Weihua Wu, Renli Zhang, Xuan Zou, Tiejian Feng, Ruxia Ding, Yue Zhang, Yao-Qing Chen, Caijun Sun, Tian Wang*, Shisong Fang* and Yuelong Shu*. The characterization of disease severity associated IgG subclasses response in COVID-19 patients. Front Immunol. 2021, 12(460).
11.Awadalkareem Adam#, Huanle Luo#, Samantha R. Osman, Binbin Wang, Christopher M. Roundy, Albert J. Auguste, Kenneth S. Plante, Bi-Hung Peng, Saravanan Thangamani, Elena I. Frolova, Ilya Frolov, Scott C. Weaver and Tian Wang*. Optimized production and immunogenicity of an insect virus-based chikungunya virus candidate vaccine in cell culture and animal models. Emerg Microbes Infect. 2021, VOL. 10.
12.Huanle Luo#, Guangyu Li#, Binbin Wang, Bing Tian, Junling Gao, Jing Zou, Shuizhen Shi, Shuang Zhu, Bi-Hung Peng, Awadalkareem Adam, Ariza Martinez, Kimberly Hein, Evandro R Winkelmann; Yoseph Mahmoud, Xiaofei Zhou, Chao Shan, Shannan Rossi, Scott Weaver, Alan D T Barrett, Wenbo Zhang, Pei-Yong Shi, Ping Wu and Tian Wang*. Peli1 signaling blockade attenuates congenital zika syndrome. PLoS Pathog. 2020, 16(6).
13.Lu Zhao#, Huanle Luo#, Doudou Huang, Ping Yu, Qiannan Dong, Caroline Mwaliko, Evans Atoni, Raphael Nyaruaba, Jiangling Yuan, Guilin Zhang, Dennis Bente, Zhiming Yuan* and Han Xia*. Pathogenesis and Immune Response of Ebinur Lake Virus: A Newly Identified Orthobunyavirus That Exhibited Strong Virulence in Mice. Front Microbiol. 2020; 11: 625661.
14.Huanle Luo#, Evandro R Winkelmann#, Shuang Zhu, Wenjuan Ru, Elizabeth Mays, Jesus A Silvas, Lauren L Vollmer, Junling Gao, Bi-Hung Peng, Nathen E Bopp, Courtney Cromer, Chao Shan, Guorui Xie, Guangyu Li, Robert Tesh, Vsevolod L Popov, Pei-Yong Shi, Shao-Cong Sun, Ping Wu , Robyn S Klein, Shao-Jun Tang, Wenbo Zhang, Patricia V. Aguilar and Tian Wang*. Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection. JCI. 2018 Nov 1;128(11):4980-4991.
15.Huanle Luo, Evandro R.Winkelmann, Ildefonso Fernandez-Salas, LiLi, Sandra V. Mayer, Rogelio Danis-Lozano, Rosa MaSanchez-Casas, NikosVasilakis, Robert Tesh, Alan D. Barrett, Scott C. Weaver and Tian Wang*. Zika, dengue and yellow fever viruses induce differential anti-viral immune responses in human monocytic and first trimester trophoblast cells. Antiviral Res. 2018 Mar;151:55-62.
16.Huanle Luo and Tian Wang*. Recent advances in understanding West Nile virus host immunity and viral pathogenesis. F1000Res. 2018; 7: 338.
17.Shuang Zhua#, Huanle Luo#, Hua Liu, Yonju Ha, Elizabeth R.Mays, Ryan E.Lawrence, Evandro Winkelmann, Alan D.Barrett, Sylvia B.Smith, MinWang, Tian Wang* and Wenbo Zhang*. p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection. Antiviral Res. 2017 Sep;145:70-81.
18.Huanle Luo, Evandro Winkelmann, Guorui Xie, Rong Fang, Bi-Hung Peng, Li Li, Helen M. Lazear, Slobodan Paessler, Michael S. Diamond, Michael Gale, Jr., Alan D. Barrett and Tian Wang*. MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection. JVI. 2017 Feb 28;91(6).
19.Huanle Luo, Zhenfeng Zhang, Zhenhua Zheng, Xianliang Ke, Xiaowei Zhang, Qian Li, Yan Liu, Bingke Bai, Panyong Mao, Qinxue Hu and Hanzhong Wang*.Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I. J Immunol. 2013 Jul 15;191(2):660-9.
招生信息
接收本科生2-3人/年进行科研培训，招收硕士生2人左右人/年。欢迎对病毒感染及宿主免疫，疫苗研发感兴趣的研究生和本科生加入！联系人：罗欢乐，联系方式：luohle@mail.sysu.edu.cn，来信请注明申请方向及职位。
