副教授,博士生导师
研究方向
1. 面向高维复杂三维基因组学数据的统计方法开发与应用
2. 机器学习算法在基因组学大数据整合分析中的应用
3. 揭示三维基因组在健康与疾病中的关键生物功能
研究简介
新型基因组学测序技术如Hi-C和single-cell Hi-C技术为理解基因组三维结构在健康和疾病中的关键生物功能提供了前所未有的机遇,课题组主要研究方向是开发和应用统计学习及深度学习模型解决三维基因组学领域的关键计算问题。
工作经历
2020/08-至今 中山大学公共卫生学院(深圳),副教授
2019/04-2020/03 美国疾控中心(CDC)数理统计师
2015/04-2019/03 美国卡内基梅隆大学(CMU)博士后(合作导师:Jian Ma)
教育经历
2010/08-2015/02 新加坡国立大学统计学与应用概率系,博士(导师:Kwok-Pui Choi)
2009/09-2011/06 东北师范大学数学与统计学院,硕士(导师:白志东)
2005/09-2009/07 东北师范大学数学与统计学院,学士
讲授课程
本科:《卫生统计学》、《医学统计学》、《数理统计方法》、《医学信息学基础》、《Python与计算生物学》、《概率论》、《医学科研概论》
研究生:《医学统计学进阶》、《医学信息学编程》、《概率论与数理统计》、《系统生物学》
承担课题及科研项目
- 国家自然科学基金面上项目,2023-2026,主持,在研
- 广东省自然科学基金面上项目,2022-2024,主持,在研
- 深圳市可持续发展科技专项,2022-2024,参与,在研
- 国家重点研发计划“病原学与防疫技术体系研究”重点专项,2021-2024,骨干人员,在研
- 中山大学高校基本科研业务费项目,2022-2022,结项,主持
- 中山大学高校基本科研业务费项目,2021-2021,结项,主持
- 中山大学“百人计划”启动项目,2020-2023,项目负责人。
发表论文
(#第一作者/共同第一作者; *通讯作者/共同通讯作者,更多文章见Google Scholar https://scholar.google.com/citations?user=noKEd4EAAAAJ&hl=en)
- Dunming Hua#, Ming Gu#, Xiao Zhang#, Yanyin Du#, Hangcheng Xie, Li Qi, Xiangjun Du, Zhidong Bai, Xiaopeng Zhu, Dechao Tian* (2024) DiffDomain enables identification of structurally reorganized topologically associating domains. Nature Communications. 15:502
a) Early version presented at RECOMB 2022. (生物信息学领域顶会,接受率~20%) - Bonnie Berger, Dechao Tian, Wei Vivian Li, Mohammed El-Kebir, Alexandru I Tomescu, Ritambhara Singh, Niko Beerenwinkel, Yu Li, Christina Boucher, Ziv Bar-Joseph (2022) What are the keys to succeeding as a computational biologist in today’s research climate? Cell Systems. 13(10):781-785
- Jiahui Tan, Yutong Zhao, Cara Burns, Dechao Tian*, Kun Zhao* (2022) Novel network method Major Minor Variation Clustering (MMVC) enables identification of poliovirus clusters with high-resolution linkages. Journal of Computational Biology
- Early version presented at MEEGID XV 2021
- Early version presented at ICCABS-CANGS 2021.
- Xiaopeng Zhu#, Yang Zhang#, Yuchuan Wang, Dechao Tian, Andrew S. Belmont, Jason R. Swedlow, Jian Ma* (2022) Nucleome Browser: an integrative and multimodal data navigation platform for 4D Nucleome. Nature Methods. 19(8):909-913
- Dechao Tian#, Ruochi Zhang#, Yang Zhang, Xiaopeng Zhu, and Jian Ma*. (2020) MOCHI enables discovery of heterogeneous interactome modules in 3D nucleome. Genome Research. 30(2): 227–238.
- Dechao Tian, Quanquan Gu*, Jian Ma* (2016) Identifying gene regulatory network rewiring using latent differential graphical models. Nucleic Acids Research. 44(17): e140.
- Liyan Chen, Ching-Yu Cheng, Hyungwon Choi, Mohammad Kamran Ikram, Charumathi Sabanayagam, Gavin SW Tan, Dechao Tian,
, Tien Yin Wong (2016) Plasma metabonomic profiling of diabetic retinopathy. Diabetes. 65(4): 1099- 1108.
- Victor Koh, Carol Y. Cheung, Xiang Li, Dechao Tian, Jie Jin Wang, Paul Mitchell, Ching-Yu Cheng, Tien Yin Wong (2016) Retinal vein occlusion in a multi-ethnic asian population: the singapore epidemiology of eye disease study. Ophthalmic Epidemiology. 23(1): 6-13.
- Gary Hin-Fai Yam, Nur Zahirah Binte M. Yusoff, Aishwarya Kadaba, Dechao Tian, Htoon Hla Myint, Roger W. Beuerman, Lei Zhou, Jodhbir S. Mehta (2015) Ex vivo propagation of human corneal stromal “activated keratocytes” for tissue engineering. Cell Transplantation. 24(9): 1845-1861.
- Liyan Chen, Jing Li, Tiannan Guo, Sujoy Ghosh, Siew Kwan Koh, Dechao Tian,
, Lei Zhou (2015) Global metabonomic and proteomic analysis of human conjunctival epithelial cells (IOBA-NHC) in response to hyperosmotic stress. Journal of Proteome Research. 14(9): 3982-3995.
- Louis Tong, Xi Yuan Zhou, Antti Jylha, Ulla Aapola, Dan Ning Liu, Siew Kwan Koh, Dechao Tian,
, Lei Zhou (2015) Quantitation of 47 human tear proteins using high resolution multiple reaction monitoring (HR-MRM) based-mass spectrometry. Journal of Proteomics. 115: 36- 48.
- Shihua Zhang#, Dechao Tian#, Ngoc Hieu Tran, Kwok-Pui Choi, Louxin Zhang (2014) Profiling human cell-type specific transcription factor regulatory networks. Nucleic Acids Research. 42(20): 12380-12387.
- Veluchamy A. Barathi, Shyam S. Chaurasia, Michael Poidinger, Siew Kwan Koh, Dechao Tian,
, Lei Zhou. (2014) Involvement of GABA transporters in atropine-treated myopic retina as revealed by iTRAQ quantitative proteomics. Journal of Proteome Research. 13(11): 4647-4658.
- Dechao Tian, Kwok-Pui Choi (2013) Sharp bounds and normalization of Wiener-type indices. PLOS ONE. 8(11): e78448.
招生信息
招收博士研究生1人/年,硕士研究生2人/年,接收本科生2-3人/年进行科研培训。欢迎具有统计学、数学、生物信息学及其它相关专业背景,热爱科学研究的同学加入我们课题组。联系方式:tiandch@mail.sysu.edu.cn。