教授，博士生导师，中山大学百人计划引进人才

公共卫生学院（深圳）副院长，深圳校区高性能计算公共平台主任

 

研究方向

1. 传染病系统流行病学（基因组和空间流行病学等）
2. 结核病传播模式及其异质性
3. 病原菌耐药及传播机制和诊断技术
4. 传染病防控策略评估（干预、模型）

工作经历

2021/05-至今 中山大学公共卫生学院（深圳） 教授

2019/02-2021/04 耶鲁大学公共卫生学院 副研究员

2016/01-2019/01 耶鲁大学公共卫生学院 博士后

2013/07-2015/12 复旦大学基础医学院 博士后

 

研究简介

主要研究方向为传染病（结核病）基因组流行病学和系统流行病学。综合运用病原生物学，基因组学，空间流行病学，生物信息学，数学模型和传统流行病学等交叉学科，从宿主群体和病原菌方面探究对疾病流行的驱动因素，包括病原菌（结核菌）传播及其异质性研究，细菌耐药性的产生、播散和演化机制研究，同时评估其对传染病诊疗和防控的作用。主持包括国自然，NIH-CTSA，NIH-UCGHI，全国博士后基金等国内外多个基金项目。已发表SCI文章30余篇，包括发表在Lancet Infectious Diseases（Lancet ID），CID，JID，BMC Medicine, Nature Eco Evo，PNAS等国际期刊。

 

教育经历

2008/09-2013/05   复旦大学生物医学研究院 病原生物学 博士

2004/09-2008/07   四川大学生命科学学院 生物科学 学士

 

承担课题及科研项目

国家科技部重点研发课题 2024-2026

国家高层次人才计划青年项目 2021-2024

广东省自然科学基金面上项目 2024-2026

广东省珠江人才团队核心成员  2023-2027

深圳市区三名工程子课题负责人  2022-2026

深圳市医学科学院前沿探索项目 2024-2026

NIH-CTSA KL2 Scholar Award  2020-2022

Patterson Trust Award  2019-2021

国家自然科学基金青年项目  2015-2017

国家博士后基金面上项目  2014-2015

 

代表性文章

（Google Scholar citations link: https://scholar.google.com/citations?user=tkeLS8YAAAAJ&hl=en)

  1. Chitwood, M.H., Colijn, C., Yang, C. et al. The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova. Nat Commun 15, 2962 (2024). https://doi.org/10.1038/s41467-024-47282-9
  2. Li, M., Zhang, Y., Wu, Z., Jiang, Y., Sun, R., Yang, J., … Yang C.*, Shen, X. *.(2024). Transmission of fluoroquinolones resistance among multidrug-resistant tuberculosis in Shanghai, China: a retrospective population-based genomic epidemiology study. Emerging Microbes & Infections, 13(1). https://doi.org/10.1080/22221751.2024.2302837
  3. Xingtong Pei, Tao Zhong, Chongguang Yang, Li Sun, Meiru Chen, Mingming Xu, Cost-Effectiveness of Community-Based Active Case Finding Strategy for Tuberculosis: Evidence From Shenzhen, China, The Journal of Infectious Diseases, Volume 229, Issue 6, 15 June 2024, Pages 1866–1877, https://doi.org/10.1093/infdis/jiae024
  4. Zhang Y, Sun R, Yu C, Li J, Lin H, Huang J, Wang Y, Shen X, Jiang Y, Yang C, Xu B. Spatial Heterogeneity of Nontuberculous Mycobacterial Pulmonary Disease in Shanghai: Insights from a Ten-Year Population-Based Study. Int J Infect Dis. 2024 Jun;143:107001. doi: 10.1016/j.ijid.2024.107001.
  5. Liu Y, Sun R, Zhang H, Huang J, Chen M, Zhan Y, Xiang J, Yuan J, Zou H, Martinez L, Yang C. Trends and predictions of tuberculosis notification in mainland China during and after the COVID-19 pandemic. J Infect. 2023 Dec;87(6):e100-e103. doi: 10.1016/j.jinf.2023.10.013.
  6. Zhang H, Sun R, Wu Z, Liu Y, Chen M, Huang J, Lv Y, Zhao F, Zhang Y, Li M, Jiang H, Zhan Y, Xu J, Xu Y, Yuan J, Zhao Y, Shen X, Yang C. Spatial pattern of isoniazid-resistant tuberculosis and its associated factors among a population with migrants in China: a retrospective population-based study. Front Public Health. 2024 Mar 6;12:1372146. doi: 10.3389/fpubh.2024.1372146.
  7. Sun R, Wu Z, Zhang H, Huang J, Liu Y, Chen M, Lv Y, Zhao F, Zhang Y, Li M, Yan J, Jiang H, Zhan Y, Xu J, Xu Y, Yuan J, Zhao Y, Shen X, Yang C. Assessing heterogeneity of patient and health system delay among TB in a population with internal migrants in China. Front Public Health. 2024 Feb 2;12:1354515. doi: 10.3389/fpubh.2024.1354515. Erratum in: Front Public Health. 2024 Mar 05;12:1391181. doi: 10.3389/fpubh.2024.1391181.
  8. Yang C, Sobkowiak B, Naidu V, Codreanu A, Ciobanu N, Gunasekera KS, Chitwood MH, Alexandru S, Bivol S, Russi M, Havumaki J, Cudahy P, Fosburgh H, Allender CJ, Centner H, Engelthaler DM, Menzies NA, Warren JL, Crudu V, Colijn C*, Cohen T*. Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis. PLoS Med. 2022 Feb 22;19(2):e1003933.
  9. X Wu, X Zhou, Y Chen, K Zhai, R Sun, G Luo, YF Lin, Y Li, C Yang*, H Zou*. The Impact of COVID-19 Lockdown on Cases of and Deaths From AIDS, Gonorrhea, Syphilis, Hepatitis B, and Hepatitis C: Interrupted Time Series Analysis. JMIR Public Health and Surveillance 9, e40591
  10. Lin H, Zhang R, Wu Z, Li M, Wu J, Shen X and Yang C (2023) Assessing the spatial heterogeneity of tuberculosis in a population with internal migration in China: a retrospective population-based study. Front. Public Health. 11:1155146. doi: 10.3389/fpubh.2023.1155146
  11. C Yang, Jian Kang; Liping Lu, Xiaoqin Guo, Xin Shen, Ted Cohen, Nicolas A Menzies. The positive externalities of migrant-based TB control strategy in a Chinese urban population with internal migration: a transmission-dynamic modelling study. BMC Medicine. 2021.
  12. Xin Shen, Wei Sha, C Yang, et al. Continuity of services for patients with tuberculosis in China in the COVID-19 era. MedRxiV. 2020. https://www.medrxiv.org/content/10.1101/2020.07.16.20150292v1
  13. Liping Lu, Qi Jiang, Jianjun Hong, Xiaoping Jin, Qian Gao, Heejung Bang, Kathryn DeRiemer, C Yang. Catastrophic costs of tuberculosis care in a population with internal migrants in China. BMC health services research. 2020 (832)
  14. Q Jiang, Q Liu, L Ji, J Li, Y Zeng, L Meng, G Luo, C Yang, HE Takiff, Z Yang, W Tan, W Yu, Q Gao. Citywide transmission of MDR-TB under China's rapid urbanization: a retrospective population-based genomic spatial epidemiological study. Clinical Infectious Diseases. 27 Aug 2019
  15. Wu, J., Yang, C., Lu L., Dai W. Detection of tuberculosis laboratory cross-contamination using whole-genome sequencing. Tuberculosis. 2019. 115:121-125
  16. Yang, C., L. Lu, J. L. Warren, J. Wu, Q. Jiang, T. Zuo, M. Gan, M. Liu, Q. Liu, K. DeRiemer, J. Hong, X. Shen, C. Colijn, X. Guo, Q. Gao and T. Cohen. Internal Migration and Transmission Dynamics of Tuberculosis in Shanghai, China: An Epidemiological, Spatial, Genomic Analysis. Lancet Infect Dis 2018.https://doi.org/10.1016/S1473-3099(18)30218-4
  17. Yang, C., T. Luo, X. Shen, J. Wu, M. Gan, P. Xu, Z. Wu, S. Lin, J. Tian, Q. Liu, Z. Yuan, J. Mei, K. DeRiemer and Q. Gao. Transmission of multidrug-resistant Mycobacterium tuberculosis in Shanghai, China: a retrospective observational study using whole-genome sequencing and epidemiological investigation. Lancet Infect Dis. 2017. 17(3): 275-284.
  18. Chen. C., Yang. C., Gao. X., Lu. Z., Tang. F., Cheng. J., Gao. Q., Cardenas. V. Community-based active case finding for tuberculosis in rural western China: a cross-sectional study. Int J Tuberc Lung Dis. 2017. 21: 1134-39
  19. Shen, X. *, Yang. C. *, J. Wu, S. Lin, X. Gao, Z. Wu, J. Tian, M. Gan, T. Luo, L. Wang, C. Yu, J. Mei, Q. Pan, K. DeRiemer, Z. Yuan and Q. Gao. Recurrent tuberculosis in an urban area in China: Relapse or exogenous reinfection? Tuberculosis (Edinb) 2017. 103: 97-104. (* Co-first author)
  20. Liu, Q., A. Ma, L. Wei, Y. Pang, B. Wu, T. Luo, Y. Zhou, H. X. Zheng, Q. Jiang, M. Gan, T. Zuo, M. Liu, Yang. C., L. Jin, I. Comas, S. Gagneux, Y. Zhao, C. S. Pepperell and Q. Gao. China's tuberculosis epidemic stems from historical expansion of four strains of Mycobacterium tuberculosis. Nat Ecol Evol. 2018
  21. Q Liu, T Zuo, P Xu, Q Jiang, J Wu, M Gan, C Yang, R Prakash, G Zhu, H Takiff and Q Gao. Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis? Emerging Microbes Infections 2018. 7: 1-8
  22. Q Jiang, L Lu, J. Wu, Yang. C., Ravi Prakash, T. Zuo, Qingyun Liu, J Hong, X. Guo, Qian Gao. Assessment of tuberculosis contact investigation in Shanghai, China: An 8-year cohort study. Tuberculosis 2018. 108:10-15
  23. Gan, M., Q. Liu, Yang. C., Q. Gao and T. Luo. Deep Whole-Genome Sequencing to Detect Mixed Infection of Mycobacterium tuberculosis. PloS One 2016. 11(7): e0159029.
  24. Xu, P., J. Wu, Yang. C., T. Luo, X. Shen, Y. Zhang, C. A. Nsofor, G. Zhu, B. Gicquel and Q. Gao. Prevalence and transmission of pyrazinamide resistant Mycobacterium tuberculosis in China. Tuberculosis (Edinb) 2016. 98: 56-61.
  25. Yang. C., Shen X, Peng Y, Lan R, Zhao Y, Long B, Luo T, Sun G, Li X, Qiao K, Gui X, Wu J, Xu J, Li F, Li D, Shen M, Hong J, Mei J, DeRiemer K and Gao Q. Transmission of Mycobacterium tuberculosis in China: A population-based molecular epidemiology study. Clin Infect Dis 2015. 61(2): 219-227
  26. Luo T, Comas I, Luo D, Lu B, Wu J, Wei L, Yang. C., Liu Q, Gan M, Sun G, Shen X, Liu F, Gagneux S, Mei J, Lan R, Wan K, Gao Q. Southern East Asian origin and coexpansion of Mycobacterium tuberculosis Beijing family with Han Chinese. Proc Natl Acad Sci U S A 2015. 112(26):8136-41.
  27. Luo T*, Yang. C. *, Peng Y, Lu L, Sun G, Wu J, Jin X, Hong J, Li F, Jian M, DeRiemer K, Gao Q. Whole-genome sequencing to detect recent transmission of Mycobacterium tuberculosis in settings with a high burden of tuberculosis. Tuberculosis 2014. 94(4), 434–440 (* Co-first author)
  28. Luo T, Yang. C., Pang Y, Zhao Y, Mei J, Gao G. Development of a Hierarchical Variable-Number Tandem Repeat Typing Scheme for Mycobacterium tuberculosis in China. PloS ONE 2014. 9(2): e89726.
  29. Peng Y*, Yang. C. *, Li X, Luo T, Li F, Gao Q. Multiple samples improve the sensitivity for detection of mixed Mycobacterium infections. Tuberculosis 2013. 94(5), 548-550. (*Co-first author)
  30. Du X, Zhu Y, Song Y, Li T, Luo T, Sun G, Yang. C, Cao C, Lu Y, Li M. Molecular analysis of Staphylococcus epidermidis strains isolated from community and hospital environments in China. PloS One 2013. 8(5): e62742
  31. Yang. C, Luo T, Sun G, Qiao K, Deriemer K, Mei J, Gao Q. Mycobacterium tuberculosis Beijing Strains Favor Transmission but Not Drug Resistance in China. Clin Infect Dis 2012. 55(9): 1179-87
  32. Luo T, Yang. C, Gagneux S, Gicquel B, Mei J, Gao Q. Combination of Single Nucleotide Polymorphism and Variable-Number Tandem Repeats for Genotyping a Homogenous Population of Mycobacterium tuberculosis Beijing Strains in China. J Clin Microbiol 2012.50(3): 633-9
  33. Sun G, Luo T, Yang. C, Dong X, Li J, Zhu Y, Zheng H, Tian W, Wang S, Barry CE, Mei J, Gao Q . Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients. J Infect Dis 2012. 206 (11): 1724-33
  34. Lan R*, Yang. C*, Lan L, Ou J, Qiao K, Liu F, Gao Q. Mycobacterium tuberculosis and non-tuberculous mycobacteria isolates from HIV-infected patients in Guangxi, China. Int J Tuberc Lung Dis 2011. 15(12): 1669-75 (*Co-first author)

 

Chapters, Books, and Reviews

1. Houben, R., H. Esmail, J. C. Emery, L. R. Joslyn, C. F. McQuaid, N. A. Menzies, J. Sanz, S. Shrestha, R. G. White, C. Yang and F. Cobelens. Spotting the old foe-revisiting the case definition for TB. 2019. Lancet Respir Med 7(3): 199-201.

2. Yang. C., Gao. Q. Recent transmission of Mycobacterium tuberculosis in China: the implication of molecular epidemiology for tuberculosis control. 2018. Frontiers of Medicine 12 (1), 76-83

 

获奖情况

中国防痨协会科学技术奖 二等奖 中国 2024

上海医学科技奖青年奖  中国 2022

上海医学科技奖 三等奖 中国 2016

上海科技进步奖 三等奖 中国 2017

中国防痨协会科学技术奖 三等奖 中国 2018

GloCal Health Fellowship Award, NIH-UCGHI 美国 2014

上海市优秀博士毕业生 中国 2013

四川省优秀毕业生 中国 2008

 

兼职情况

担任以下杂志同行评阅人：
American Journal of Tropical Medicine and Hygiene

BMC Medicine

BMC Genomics

BMC infectious diseases

Environment International

European Journal of Clinical Microbiology &infectious Diseases

Frontiers in Microbiology

Frontiers in Medicine

International journal of Infectious Disease

Infectious Diseases of Poverty

Journal of Infectious Diseases

Journal of Global Antimicrobial Resistance

Lancet Infectious Diseases

Nature communications

PloS One

Scientific Reports

The International Journal of Tuberculosis and Lung Diseases

Tuberculosis

担任以下机构评审工作：
国家自然科学基金会 （NSFC）

Antibiotics（Topic editor）

 

研究生培养

已毕业1名博士，9名硕士

 

招生信息

接收本科生2-4人/年进行科研培训，招收博士生、硕士生2-4人/年，常年招收博士后以及专职科研（研究员、副研究员）。欢迎对流行病与卫生统计学、生物信息学、系统流行病学、空间流行病学、网络科学、数学模型方向感兴趣，特别对传染病病原菌（结核菌）基因组进化、流行规律和传播网络解析、耐药发生和播散演化机制、系统发育和群体遗传学解析，系统流行病学感兴趣的预防医学、生命科学、基础医学、数学以及计算机方向的博士后、研究生和本科生加入我们的研究团队！联系人：杨崇广，联系方式：yangchg9@mail.sysu.edu.cn ，来信请注明申请方向及职位。