副教授，博士生导师，中山大学百人计划引进人才

 

个人简介

中山大学“百人计划”引进人才，瑞典卡罗林斯卡医学院流行病学助理教授，德国神经退行性疾病研究中心独立PI，神经流行病学课题组长、博士生导师。本科、硕士和博士分别就读于山东大学、复旦大学和瑞典卡罗林斯卡医学院。曾获得复旦大学优秀毕业生（2012），国家优秀自费留学生奖学金（2017）和美国国立衰老研究所（NIA）端粒研究网络先锋奖（2021），主持神经流行病学等课题研究经费125万欧元。主要从事衰老、老年病和神经退行性疾病等流行病学的病因学研究工作，累计发表英文论文90余篇，部分研究成果发表在Am J Epi, Eur J Epi, Neuroepidemiol, JAMA Neurol, BMJ Mental Health, Annals of Neurol, J Prev Alzheimers Dis, Alzheimers Res Ther, Circ Res, Heart, Diabetologia, J Nutr等杂志。担任深圳市预防医学会流行病学分会副主任委员、教育部国家留学基金委通讯评审专家等职。

 

研究方向

神经退行性疾病流行病学、端粒和生物学衰老、生存分析统计分析方法

 

工作经历

2012-2014        德国Greifswald大学口腔流行病学研究助理、玛丽居里学者(Marie Currie Early Stage Researcher: ESR)

2018-2019        瑞典卡罗林斯卡医学院神经流行学博士后

2020.1-2021.5  德国亥姆霍兹国家研究中心联合会(Helmholtz Association)-德国神经退行性疾病研究中心(DZNE)独立PI、神经流行病学课题组长(Junior Group Leader)、瑞典卡罗林斯卡医学院助理教授、博士生导师

2021.6至今       中山大学 副教授、博士生导师

 

教育经历

2004-2009 山东大学预防医学/法学专业

2009-2012 复旦大学流行病与卫生统计专业

2014-2018 瑞典卡罗林斯卡医学院流行病学专业

 

讲授课程

流行学、卫生统计学、遗传流行病学、流行病学中的因果推断技术、卫生法学

 

承担课题及科研项目

中山大学百人计划、德国亥姆霍兹国家研究中心联合会-德国神经退行性疾病研究中心神经流行病学项目、瑞典卡罗琳斯卡医学院基金等项目约1000万人民币

 

代表性文章

  1. Yu Wang, Meijie Ye, Qianqian Ji, Qi Liu, Xiaowei Xu, Yiqiang Zhan*. The Longitudinal Trajectory of CSF sTREM2. the Alzheimer’s Disease Neuroimaging Initiative. Alzheimer's Research & Therapy. 2024.

 

  1. Yu Wang, Meijie Ye, Qianqian Ji, Qi Liu, Xiaowei Xu, Yiqiang Zhan*. Association between Cerebrospinal Fluid sTREM2 Levels and Depression. the Alzheimer's Disease Neuroimaging Initiative Study. The Journal of Prevention of Alzheimer's Disease. 2024.

 

  1. Qianqian Ji, Weishan Lian, Yaxian Meng, Weifeng Liu, Mansi Zhuang, Nan Zheng, Ida K. Karlsson, Yiqiang Zhan*. Cytomegalovirus Infection and the Risk of Alzheimer's Disease. A Meta-Analysis. The Journal of Prevention of Alzheimer's Disease. 2024; 11(2).422-427.

 

  1. Aijie Zhang, Liqiong Zhou, Yaxian Meng, Qianqian Ji, Qi Liu, Meijie Ye, Weiri Tan, Yeqi Zheng, Zhao Hu, Miao Liu, Xiaowei Xu, Ida K. Karlsson, Sara Hägg, Yiqiang Zhan*. Association between Psychological Resilience and All-cause Mortality in the Health and Retirement Study. BMJ Mental Health. 2024.

 

  1. Zhuochang Bi, Yaxian Meng, Qianqian Ji, Aijie Zhang, Miao Liu, Xiaowei Xu, Yiqiang Zhan*. Association between Volatile Organic Compounds and Serum Neurofilament Light Chain in US adults. Science of the Total Environment. 2024. 926.171893.

 

  1. Yuxia Wei, Yiqiang Zhan*, Tuomi Tiinamaija, Josefin Edwall Löfvenborg, Sofia Carlsson. Birth weight, BMI in adulthood and latent autoimmune diabetes in adults. A Mendelian randomization study. Diabetologia. 2022. 65(9).1510-1518.

 

  1. Elisa Longenitti, Yiqiang Zhan*, Karin Wirdefeldt, Fang Fang. Heart Rate, Intelligence in Adolescence, and Parkinson’s Disease Later in Life. European J Epidemiology. 2021; 36(10).1055-1064.

 

  1. Fang Fang, Yiqiang Zhan*, Niklas Hammar, Xia Shen, Karin Wirdefeldt, Göran Walldius, Daniela Mariosa. Blood biomarkers of carbohydrate, lipid, and apolipoprotein metabolisms and risk of Parkinson's disease. the Swedish AMORIS cohort and Mendelian randomization analysis. Circulation Research. 2019; 125(6).643-652.

 

  1. Yiqiang Zhan*, Fang Fang. Smoking and Amyotrophic lateral sclerosis. A Mendelian Randomization Study. Annals of Neurology. 2019. 85 (4), 482-484.

 

  1. Yiqiang Zhan*, Xing-rong Liu, Chandra A. Reynolds, Nancy L Pedersen, Sara Hägg, Mark Clements. Telomere Length and All-cause Mortality. A Between-within Twin Analysis using Generalized Survival Model. American Journal of Epidemiology. 2018; 187(10).2186-2191.

 

  1. Yiqiang Zhan*, Ida K Karlsson, Robert Karlsson, Annika Tillander, Chandra A Reynolds, Nancy L Pedersen, Sara Hägg. Exploring the Causal Pathway from Telomere Length to Coronary Heart Disease. A Network Mendelian Randomization Study. Circulation Research. 2017; 121(3).214-219.

 

  1. Yiqiang Zhan*, Ci Song, Robert Karlsson, Annika Tillander, Chandra A. Reynolds, Nancy L. Pedersen, Sara Hägg. Telomere length shortening and Alzheimer's disease. A Mendelian Randomization study. JAMA Neurology. 2015; 72(10).1202-1203.

其他论文：

  1. Xiaoping Huang, Yaxian Meng, Xinyi Hu, Aijie Zhang, Qianqian Ji, Zhirou Liang, Fang Fang, Yiqiang Zhan*. Association between Cytomegalovirus Seropositivity and All-Cause Mortality. An Original Cohort Study. Journal of Medical Virology. 2024. 96(2).e29444.

 

  1. Zhao Hu, Lu Tang, Yiqiang Zhan*. Depression, stress-related disorders and risk for dental caries and periodontitis. A bidirectional and multivariable Mendelian randomization study. Journal of Affective Disorders. 2024. 361.285-290.

 

  1. Meijie Ye, Qianqian Ji, Qi Liu, Yue Xu, Enxiang Tao, Yiqiang Zhan*. Olfactory dysfunction and long-term trajectories of sleep disorders among early Parkinson's disease. findings from a longitudinal cohort. Neuroepidemiology. 2024.

 

  1. Meijie Ye, Xiaoying Kang, Ida K. Karlsson, Yu Wang, Qianqian Ji, Qi Liu, Xiaowei Xu, Sara Hägg, Fang Fang, Karin Wirdefeldt, Yiqiang Zhan*. Associations between Sleep Disorders and Impulsive-Compulsive Behaviors in Parkinson's Disease. A Prospective Cohort Study. Neuroepidemiology. 2024.

 

  1. Aijie Zhang, Yasi Zhang, Yaxian Meng, Qianqian Ji, Liqiong Zhou, Miao Liu, Yi Chao, Ida K. Karlsson, Fang Fang, Sara Hägg, Yiqiang Zhan*. Associations between Psychological Resilience and Epigenetic Clocks in the Health and Retirement Study. GeroScience. 2024; 46(1).961-968.

 

  1. Xiaogang Lv, Qingya Zhao, Qi Liu, Qianqian Ji, Liqiong Zhou, Zhao Hu, Miao Liu, Yiqiang Zhan*. Serum Fatty Acid Profiles and Neurofilament Light Chain Levels in the General Population. Journal of Nutrition. 2024.

 

  1. Qi Liu, Qingya Zhao, Qianqian Ji, Xiaogang Lv, Xiaoping Huang, Xiaowei Xu, Yiqiang Zhan*. Trends of Mortality from Epilepsy in the United States, 1979-2021. Seizure. 2024.

 

  1. Zhao Hu, Lu Tang, Xiaowei Xu, Yiqiang Zhan*. Association between physical activity and psychosocial status in adults with epilepsy. Results from the 2022 National Health Interview Survey. Epilepsy & Behavior. 2024.

 

  1. Zhao Hu, Lu Tang, Yiqiang Zhan* Cognition as mediator of pulmonary function and risk of sarcopenia among older adults. BMC Public Health. 2024.

 

  1. Qingya Zhao, Qi Liu, Xiaogang Lv, Zhao Hu, Yiqiang Zhan*. Association between Serum Folate Concentrations and All-Cause Mortality in U.S. adults. A Cohort Study Based on National Health and Nutrition Examination Survey III. Frontiers in Nutrition. 2024.

 

  1. Nan Zheng, Mansi Zhuang, Yanan Zhu, Yu Wang, Meijie Ye, Yasi Zhang, Yiqiang Zhan*. Association between Psychological Resilience and Body Mass Index in a Community-Based Population. A Cross-Sectional Study. Obesity Science & Practice. 2024.

 

  1. Yanan Zhu, Yasi Zhang, Mansi Zhuang, Meijie Ye, Yu Wang, Nan Zheng, Yiqiang Zhan*. Association between Sleep Duration and Psychological Resilience in a Population-based Survey. A Cross-Sectional Study. Journal of Education and Health Promotion. 2024.

 

  1. Qizheng Zhao, Manting Chen, Leiwei Fu, Yan Yang, Yiqiang Zhan*. Assessing and Projecting the Global Burden of Thyroid Cancer, 1990-2030. Analysis of the Global Burden of Disease Study. Journal of Global Health. 2024; 14.04090.

 

  1. Yaxian Meng, Qianqian Ji, Aijie Zhang, Yiqiang Zhan*. Trends in the prevalence and incidence of chronic obstructive pulmonary disease among adults aged ≥ 50 years in the United States, 2000-2020. Chronic Diseases and Translational Medicine. 2024.

 

  1. Danqi Huang, Siqi Lin, Juanting He, Qi Wang, Yiqiang Zhan*. Association between COVID-19 and telomere length. a bidirectional Mendelian randomization study. Journal of Medical Virology. 2022. 94(11).5345-5353.

 

  1. Xiaoping Huang, Chao Yi, Qianqian Ji, Yaxian Meng, Aijie Zhang, Chongguang Yang, Liqiong Zhou, Yiqiang Zhan. Association between Cytomegalovirus Infection and Cancer-related Mortality in US Adults. Yiqiang Zhan*. 2023. 87.102487.

 

  1. Yi Teng, Danqi Huang, Ruixi Li, Chao Yi, Yiqiang Zhan*. Association between telomere length and risk of lung cancer in an Asian population. a Mendelian Randomization study. World Journal of Oncology. 2023. 14(4).277-284.

 

  1. Huang H, Huang X, Liao J, Li Y, Su Y, Meng Y, Yiqiang Zhan*. Sex-specific non-linear associations between body mass index and impaired pulmonary ventilation function in a community-based population. Longgang COPD study. Front Pharmacol. 2023 Mar 9;14.1103573.

 

  1. Yanan Zhu, Yaxian Meng, Yasi Zhang, Ida K. Karlsson, Sara Hägg, Yiqiang Zhan*. Genetically Determined Telomere Length and Its Association with Chronic Obstructive Pulmonary Disease and Interstitial Lung Disease in Biobank Japan. A Mendelian Randomization Study. Heliyon. 2023. 10(1).e23415.

 

  1. Yasi Zhang, Yanan Zhu, Meijie Ye, Yong Mao, Yiqiang Zhan*. Telomere length and its association with systemic lupus erythematosus in an Asian population. A Mendelian randomization study. Lupus. 2023.

 

  1. Yasi Zhang, Aijie Zhang, Jianbang Xiang, Yiqiang Zhan*. Perceived Stress and Cardiovascular Disease in a Community-Based Population. Heart and Mind. 2022.

 

  1. Yiqiang Zhan*, Xiaoying Kang. Disentangling the Causal Effect of Telomere Length in Systemic Lupus Erythematosus Using Genetic Variants as Instruments. Arthritis & Rheumatology. 2022.

 

  1. Meijie Ye, Yu Wang, Yiqiang Zhan*. Genetic association of leukocyte telomere length with Graves' disease in Biobank Japan. a two-sample Mendelian randomization study. Front Immunology. 2022.

 

  1. S Hägg, Yiqiang Zhan*. Telomere research entering the big data era. Nat Aging. 2022.

 

  1. J Sieurin, Yiqiang Zhan*, N Pedersen, K Wirdefeldt. Neuroticism, smoking and the risk of Parkinson's disease. Journal of Parkinson's Disease. 2021.

 

  1. Yiqiang Zhan*, Sara Hägg. Association between Genetically Predicted Telomere Length and Facial Skin Aging in UK Biobank. a Mendelian Randomization Study. GeroScience. 2021.

 

  1. Ruoqing Chen, Yiqiang Zhan*. Telomere length and Parkinson's disease. A Mendelian randomization study. Neurobiology of Aging. 2020 July.

 

  1. Yiqiang Zhan*, Mark Clements, Rosebud Roberts, Maria Vassilaki, Brooke Druliner, Lisa Boardman, Ronald Petersen, Chandra A. Reynolds, Nancy L. Pedersen, Sara Hägg. Association of Telomere Length with General Cognitive Trajectories. A Meta-Analysis of Four Prospective Cohort Studies. Neurobiology of Aging. 2018. 69(9).111-116.

 

兼职情况

担任BMC Medical Research Methodology编委

担任以下杂志审稿人：Alzheimer’s Research and Therapy (2021-), GeroScience (2021-), Translational Neurodegeneration (2021-),Human Molecular Genetics (2020-), PLoS Genetics (2020-), Annals of Neurology (2019-), Journal of Neurology, Neurosurgery, and Psychiatry(2019-), International Journal of Epidemiology (2019-), American Journal of Clinical Nutrition (2019-), British Medical Journal (2018-), Alzheimer’s & Dementia (2018-), Aging Cell (2018-), European Journal of Epidemiology (2017-), European Heart Journal (2016-)

 

招生信息

在流行病与卫生统计专业和公共卫生专业招生，已培养毕业博士研究生1名、硕士研究生7名，在读博士生3名，在读硕士研究生4名。

 

团队介绍

课题组与瑞典卡罗林斯卡医学院、德国神经退行性疾病研究中心、美国UC Riverside、澳大利亚墨尔本大学的合作方保持良好的合作关系，共同培养研究生。