副教授，博士生导师
研究方向
1. 模式生物研究宿主-病原交互机制（病毒学，先天免疫，功能基因组学及遗传学等）
2. 传染病的病原生物学（微生物学，分子病毒学及宏基因组学等）
研究简介
本课题组主要研究方向是利用独特感染模式生物线虫的新病毒研究模型以探究从线虫到高等生物进化保守的宿主-病毒相互作用机制。目前，利用该模型已发现多个新型宿主-病毒交互机制，其中包括TNK2-NCK1-WASL促病毒感染通路，HIP1/HIP1R促病毒感染因子以及TUT4/7抗病毒先天免疫新机制等。同时，利用宏基因组学及分子病毒学研究传染病的病原生物学，已发现多个导致小儿腹泻的新型星状病毒MLB和VA等。相关文章发表在PNAS，eLIFE，mBio，NSMB和JVI等国际期刊上。
工作经历
2022.03至今 中山大学 公共卫生学院（深圳） 副教授
2021.04-2022.02 中科院重庆绿色智能技术研究院 生物医药与健康所 项目研究员
2016.10-2021.03 美国圣路易斯华盛顿大学 医学院 专职研究员（Staff Scientist）
2011.09-2016.09 美国圣路易斯华盛顿大学 医学院 博士后研究助理
教育经历
2006.09-2011.07 中国科学院 上海巴斯德研究所 博士
2002.09-2006.07 重庆大学 生物工程学院 学士
承担课题及科研项目
2024-2026，深圳市医学研究专项资金，前沿探索项目，项目负责人；
2024-2026，国家自然科学基金委，专项项目，项目负责人；
2023-2026，国家自然科学基金委，面上项目，项目负责人；
2022至今，主持中山大学“百人计划”启动项目；
2021-2022，主持中国科学院“百人计划”B类备案启动项目。
代表性文章
1.Jiang H, Joshi A, Gan T, Janowski AB, Fujii C, Bricker TL, Darling TL, Harastani HH, Seehra K, Chen H, Tahan S, Jung A, Febles B, Blatter JA, Handley SA, Parikh BA, Wang D, Boon ACM. 2023. The Highly Conserved Stem-Loop II Motif Is Dispensable for SARS-CoV-2. J Virol doi:10.1128/jvi.00635-23:e0063523
2. Jiang, H.*†, Sandoval, L.E.*, Leung, C., Wang, D†. (2020). Huntingtin-interacting protein family members have a conserved pro-viral function from Caenorhabditis elegans to humans. Proc. Natl. Acad. Sci. U.S.A. 117(36):22462-22472.
3. Guo, Y. R.*, Fan, Y.*, Zhou, Y., Jin, M., Zhang, J.L., Jiang, H., Holt, M. V., Wang, T., Young, N. L., Wang, D., Zhong, W.†, Yizhi J. Tao†. (2020). Orsay CP-delta adopts a novel beta-bracelet structural fold and incorporates into virions as a head fiber. Journal of virology doi: 10.1128/JVI.01560-20.
4. Jiang, H.†, Leung, C., Tahan, S., Wang, D†. (2019). Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL and NCK1. eLIFE 8 doi: https://doi.org/10.1101/737635.
5. Richaud, A., Frézal, L., Tahan, S., Jiang, H., Blatter, J.A., Zhao, G., Kaur, T., Wang, D.†, Félix, M.A.† Vertical transmission in Caenorhabditis nematodes of RNA molecules encoding a viral RNA-dependent RNA polymerase. (2019). Proc. Natl. Acad. Sci. U.S.A. 116:24738-24747.
6. Sowa, J. N., Jiang, H., Somasundaram, L., Wang, D., Troemel, E. R. (2019). The C. elegans RIG-I homolog drh-1 activates the Intracellular Pathogen Response upon viral infection. Journal of virology doi: 10.1128/JVI.01173-19.
7. Sandoval, L.E., Jiang, H., Wang, D. (2019). The Dietary Restriction Like (drl-1) Gene, a Putative Serine/ Threonine Kinase, is Essential for Orsay virus Infection in C. elegans. Journal of virology 93 (3) doi: 10.1128/JVI.01400-18.
8. Le Pen, J., Jiang, H.*, Di Domenico*, T., Kneuss, E., Kosalka, J., Leung, C., Morgan, M., Much, C., Rudolph, K.L.M., Enright, A.J., O'Carroll, D., Wang, D., Miska, E.A. (2018). Terminal uridylyltransferases target RNA viruses as part of the innate immune system. Nature Structural & Molecular Biology 25:778-786.
9. Jiang, H., Wang, D. (2018). The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses. Viruses 10 (2) doi: 10.3390/v10020085.
10. Jiang, H., Chen, K., Sandoval, L.E., Leung, C., Wang, D. (2017). An evolutionarily conserved pathway essential for Orsay virus infection of Caenorhabditis elegans. mBio 8:e00940-17.
11. Chen, K., Franz, C.J., Jiang, H., Jiang, Y., Wang, D. (2017). An evolutionarily conserved transcriptional response to viral infection in Caenorhabditis nematodes. BMC genomics 18:303.
12. Jiang, H., Franz, C.J., Wang, D. (2014). Engineering Recombinant Orsay Virus Directly in the Metazoan Host Caenorhabditis elegans. Journal of virology 88:11774-11781.
13. Guo, R.Y., C.F.H., Jakana, J., Jiang, H., Wang, D., Chiu, W., Zhong, W., Tao, Y.J. (2014). The crystal structure of a nematode-infecting virus. Proc. Natl. Acad. Sci. U.S.A. 111:12781-12786.
14. Holtz, L.R., Bauer, I.K., Jiang, H., Belshe, R., Freiden, P., Schultz-Cherry, S.L., Wang, D. (2014). Seroepidemiology of Astrovirus MLB1. Clinical and vaccine immunology : CVI 21, 908-911.
15. Jiang, H., Franz, C.J., Wu, G., Renshaw, H., Zhao, G., Firth, A.E., Wang, D. (2014). Orsay virus utilizes ribosomal frameshifting to express a novel protein that is incorporated into virions. Virology 450-451, 213-221.
16. Jiang, H., L. R. Holtz, I. Bauer, C. J. Franz, G. Zhao, L. Bodhidatta, S. K. Shrestha, G. Kang, and D. Wang. (2013). Comparison of novel MLB-clade, VA-clade and classic human astroviruses highlights constrained evolution of the classic human astrovirus nonstructural genes. Virology 436(1), 8-14.
17. Wang, Q., Weng, L., Jiang, H., Zhang, S., Toyoda, T. (2013). Fluorescent primer based in vitro transcription system of viral RNA-dependent RNA polymerases. Analytical biochemistry 433(2), 92-94.
18. Jiang, H., Weng, L., Zhang, N., Arita, M., Li, R., Chen, L., and Toyoda, T. (2011). Biochemical characterization of enterovirus 71 3D RNA polymerase. BBA-Gene Regulatory Mechanism 1809(3), 211-9.
19. Jiang, H., Xu, Y., Li, L., Weng, L., Wang, Q., Zhang, S., Jia, B., Hu, H., He, Y., Jacob, Y., Toyoda, T. (2011). Inhibition of influenza virus replication by constrained peptides targeting nucleoprotein. Antiviral chemistry & chemotherapy 22, 119-130.
20. Jiang, H.*, Zhang, S.*, Wang, Q., Wang, J., Geng, L., and Toyoda, T. (2010). Influenza virus genome C4 promoter/origin attenuates its transcription and replication activity by the low polymerase recognition activity. Virology 408(2), 190-6.
21. Wang, Q., Zhang, S., Jiang, H., Wang, J., Weng, L., Mao, Y., Sekiguchi, S., Yasui, F., Kohara, M., Buchy, P., Deubel, V., Xu, K., Sun, B., Toyoda, T. (2012). PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection. Virology journal 9, 106.
22. Wang, H., Li, Y., Liu, L., Jiang, H., and Deng, X. (2006). Influence of the substrate stretch on the morphology regulation of the A549 cells. Journal of Medical Biomechanics 21(2), 100-04. [Chinese]
23. Wang, H., Tang, Z., Jiang, H., Liu, L., and Deng, X. (2006). Study of the morphological changes and cells interaction in cardiomyocytes at low temperature. Journal of Medical Biomechanics 21(4), 267-71. [Chinese]
* These two authors contributed equally. †Co-corresponding author.
获奖情况
获华盛顿大学Stephen-Morse博士后基金奖励
招生信息
本课题组热忱欢迎热爱科学研究的优秀学生报考硕士和博士研究生（2-3人/年）；并接收本科生进行科研培训实习（2-3人）；常年招收博士后等。欢迎对病毒学、免疫学、基因组学、遗传学及生物信息学等研究方向感兴趣的有志之士加入本课题组！请有意者将个人简历和科研成果通过电子邮件发至：jianghb8@mail.sysu.edu.cn，来信请注明申请方向及职位。
