教授，博士生导师

卫生统计学与系统生物学教研室

 

科研简介

科研哲学是揭示复杂现象中的简单美,服务全民健康。研究方向聚焦传染病计算系统生物学，开展相关基础与应用研究，侧重综合运用统计学习、理论建模以及高通量实验技术等手段，整合从微观到宏观的多维异质信息，定量研究多种系统因素与传染病的产生、演化、传播、感染免疫以及致病的复杂关系，揭示并定量描述背后隐藏规律及其机制，指导传染病日常监测、预警、防控与治疗。代表性成果包括基于序列流感快速准确抗原预测与疫苗株推荐，融合多维信息的季节性流感长期预测，融合统计建模与机制建模的传染病复杂场景模拟预测与评估，基于突变网络框架的病原体演化与传播分析，以及复杂感染免疫表型的系统生物学机制解析与应用等，研究成果先后在Science Translational Medicine, Nature Communications, Genome Research, Nucleic Acids Research, Briefings in Bioinformatics, PLoS Pathogen, Journal of Virology and Emerging Microbes & Infections等高水平杂志上发表。课题组公众号DuLab计算生物学。

 

研究方向

1.流行病与卫生统计学/生物信息学/计算与系统生物学

2.传染病分子演化与传播规律解析、理论建模与预测预警

3.感染免疫系统生物学研究以及公共卫生与医学大数据深度挖掘

 

工作经历

2018/01 -  至今       中山大学公共卫生学院（深圳），教授

2015/12-2017/12   芝加哥大学生态进化系，研究专员

2014/10-2015/11   霍华德休斯医学研究所（HHMI），研究助理（密歇根大学、芝加哥大学）

2010/09-2014/09   美国国立卫生院（NIH）国立生物信息学中心（NCBI），博后

 

教育经历

2005/09-2010/07   中国科学院生物物理研究所，生物信息学，理学博士

2001/09-2005/07   华中科技大学物理系，应用物理学，理学学士

 

讲授课程

  1. 本科：卫生统计学、医学统计学、Python与数据科学、医学信息学基础
  2. 研究生：医学统计学进阶、医学信息学编程、公共卫生领导力、定量与系统医学、公共卫生与人工智能

 

社会兼职

  1. 中国生物工程学会计算生物学与生物信息学专委会副主任委员
  2. 中国生物物理学会医学信息学分会委员
  3. 中华预防医学会生物信息学专委会委员
  4. 中华医学会医学信息学分会委员
  5. 中国微生物学会智能计算微生物学专委会委员

 

代表性成果

本课题组研究方向聚焦传染病系统交叉研究，针对目前传染病防控被动局面，融合微观演化、宏观传播与人群免疫信息，综合利用人工智能、数学建模与多组学技术，推进变异规律解析与预测、流行传播规律解析与预测以及人群免疫力定量解析与应用，辅助传染病精准科学防控。

变异规律解析与预测：病原体优势变异株预测对于精准传染病预测预警与防控至关重要，然而，由于我们对其影响因素及其规律缺乏全面理解，导致流行株及其对流行传播影响效果预测受限。病原体微观分子变异受自身蛋白结构及功能约束，同时也受到宿主免疫系统选择，在群体层面也存在竞争与淘汰，因此，要想有效识别优势变异株或预测变异方向，需综合考虑这些系统影响因素，了解清楚其中规律。从变异预测相关的微观、宏观及免疫系统影响因素的角度出发，发展创新理论方法来推进传染病病原体变异预测是本课题组其中的一个重要的研究方向，目前已在Nature Communications，Journal of Infections， Briefings in Bioinformatics等发表了相应成果。

 

传播规律解析与预测：传染病的流行传播受众多因素的影响，包括病原体本身变化、环境及群体因素以及宿主免疫规律等。传染病规律解析与模拟预测取决于影响因素与影响方式的有效识别，并在此基础上构建合适的理论模型，以实现有效模拟与预测预警。目前数据驱动的统计学习方法和机制驱动的数学建模方法在传染病建模方面都有广泛应用。本课题组致力于通过统计学习方法不断推进传染病流行传播影响因素及影响方式的有效解析，并在此基础上不断升级动力学机制建模以及整合统计人工智能和物理机制约束的融合建模以实现真实场景复杂传染病流行传播长效预测。目前该方向的相关成果已发表在Science Translational Medicine，Emerging Microbes & Infections，PLoS Pathogen等。

 

人群免疫力定量解析：传染病变异及传播必然受宿主免疫系统影响，同时宿主系统是一个庞大复杂的生物系统，因此传染病的有效防控需要考虑宿主本身复杂互作系统以及病原体与宿主互作系统。这方面的深入研究也将对药物设计、疫苗设计、疫苗策略及防控策略设计提供机制理论指引。本课题组致力于基于复杂系统解构视角推进传染病相关人群免疫力数字解码，目前已构建了自然健康人群抗体库跟踪队列以及免疫力跟踪队列，从宿主基因组、转录组和抗体库等高通量组学角度开展研究与应用。相应成果已发表在Emerging Microbes & Infections，Briefings in Bioinformatics，Frontiers in Immunology等。

 

承担主要课题

  1. 国家自然科学基金委员会专项项目, 2025- 2027, 参与，在研
  2. 广州国家实验室专项项目， 2024-2028，参与，在研
  3. 国家重点研发计划病原学与防疫技术体系研究专项， 2023-2025，参与，在研
  4. 国家重点研发计划病原学与防疫技术体系研究专项， 2022-2024，参与，结题
  5. 广东省重点领域研发计划生物安全技术专项， 2022-2025，参与，在研
  6. 国家自然科学基金国际（地区）合作与交流项目， 2020-2024，参与，结题
  7. 科学技术部社会发展科技司，2022-2023，主持，结题
  8. 国家自然科学基金面上项目， 2020-2023，主持，结题
  9. 广东省自然科学基金面上项目，2021-2023，主持，结题
  10. 深圳市高层次人才团队项目，2019-2024，参与，结题
  11. 深圳市技术攻关重点项目，2020-2023，参与，结题
  12. 深圳市稳定支持重点项目，2020-2023，参与，结题
  13. 广东省重点领域研发计划科技攻关专项， 2021-2022，主持，结题
  14. 广东省重点领域研发计划防控减灾与应急救援专项，2020-2022，参与，结题
  15. 广东省重点领域研发计划精准医学专项， 2019-2022，参与，结题
  16. 国家重点研发计划公共安全风险防控与应急技术装备应急专项，2020-2021，参与，结题
  17. 国家海外高层次人才项目， 2017-2020，主持，结题

 

代表性论文

  1. Jian Chen, Daoze Wang, Jialu Zheng, Bing Zhang, Yilin Chen, Haoyu Long, Jinfeng Zeng, Zicheng Cao, Wenjie Han, Gang Wang, Xue Zhang, Jianyun Lu*, Zhoubin Zhang*, Xiangjun Du*; Trends and factors influencing over-the-counter cold and cough medication sales in Guangzhou, China: 2011–2017. BMC Infectious Diseases, 2025 Jun【IF=3.6/JCR2区/中科院三区】
  2. Haoyu Long, Yilin Chen, Jingru Feng, Jian Chen, Xue Zhang, Wenjie Han, Min Kang, Xiangjun Du*; Annual global dengue dynamics are related to multi-source factors revealed by a machine learning prediction analysis. PLoS Negl Trop Dis 2025 Jun 19(6): e0013232.【IF=3.2/JCR1区/中科院二区】
  3. Jialu Zheng, Jinfeng Zeng, Haoyu Long, Jian Chen, Kaijie Liu, Yixiong Chen*, Xiangjun Du*; Recombination and selection trajectory of the monkeypox virus during its adaptation in the human population. Journal of Medical Virology, 2024 Jul;96(7): e29825 【IF=6.8/JCR1区/中科院三区】
  4. Ke Zhai, Jinze Dong, Jinfeng Zeng, Peiwen Cheng, Xinsheng Wu, Wenjie Han, Yilin Chen, Zekai Qiu, Yong Zhou, Juan Pu*, Taijiao Jiang*, Xiangjun Du*. Global antigenic landscape and vaccine recommendation strategy for low pathogenic avian influenza A (H9N2) viruses. Journal of Infection, 2024 Jun;89(2):106199 【IF=14.3/JCR1区/中科院一区】
  5. Kang Tang, Qianru Sun, Jinfeng Zeng, Jing Tang, Peiwen Cheng, Zekai Qiu, Haoyu Long, Yilin Chen, Chi Zhang, Jie Wei, Xiaoping Qiu, Guozhi Jiang, Qianglin Fang, Litao Sun, Caijun Sun, Xiangjun Du*. Network-based approach for drug repurposing against mpox. International Journal of Biological Macromolecules, 2024 Jun;270(2):132468 【IF=7.7/JCR1区/中科院一区】
  6. Yilin Chen#, Feng Tang#, Zicheng Cao, Jinfeng Zeng, Zekai Qiu, Chi Zhang, Haoyu Long, Peiwen Cheng, Qianru Sun, Wenjie Han, Kang Tang, Jing Tang,Yang Zhao, Dechao Tian, Xiangjun Du*. Global pattern and determinant for interaction of seasonal influenza viruses. Journal of Infection and Public Health, 2024 Jun;17(6):1086-1094 【IF=4.7/JCR1区/中科院三区】
  7. Peiwen Cheng, Ke Zhai, Wenjie Han, Jinfeng Zeng, Zekai Qiu, Yilin Chen, Kang Tang, Jing Tang, Haoyu Long, Taijiao Jiang*, Xiangjun Du*. Characterizing the antigenic evolution of pandemic influenza A (H1N1) pdm09 from 2009 to 2023. Journal of Medical Virology, 2024 May;96(5): e29657 【IF=6.8/JCR1区/中科院三区】
  8. Jinfeng Zeng#, Fanshu Du#, Linna Xiao, Honglei Sun, Lu Lu, Weipan Lei, Jialu Zheng, Lu Wang, Sicheng Shu, Yudong Li, Qiang Zhang, Kang Tang, Qianru Sun, Chi Zhang, Haoyu Long, Zekai Qiu, Ke Zhai, Zhichao Li, Geli Zhang, Yipeng Sun, Dayan Wang, Zhengwang Zhang, Samantha J. Lycett, George F. Gao, Yuelong Shu, Jinhua Liu, Xiangjun Du*, and Juan Pu*. Spatiotemporal genotype replacement of H5N8 avian influenza viruses contributed to H5N1 emergence in 2021/2022 panzootic. Journal of Virology, 2024 Mar;98(3):e0140123 【IF=4/JCR2区/中科院一区】
  9. Guoqin Mai#, Chi Zhang#, Chunhong Lan#, Jie Zhang, Yuanyuan Wang, Kang Tang, Jing Tang, Jinfeng Zeng, Yilin Chen, Peiwen Cheng, Shuning Liu, Haoyu Long, Qilan Wen, Aqin Li, Xuan Liu, Ruitong Zhang, Shuyang Xu, Lin Liu, Yanlan Niu, Lan Yang, Yihan Wang, Di Yin, Caijun Sun, Yaoqing Chen, Wei Shen*, Zhenhai Zhang*, Xiangjun Du*. Characterizing the dynamics of BCR repertoire from repeated influenza vaccination. Emerging microbes & infections, 2023 Dec;12(2):2245931 【IF=8.4/JCR1区/中科院一区】
  10. Qianru Sun, Jinfeng Zeng, Kang Tang, Haoyu Long, Chi Zhang, Jie Zhang, Jing Tang, Yuting Xin, Jialu Zheng, Litao Sun, Siyang Liu and Xiangjun Du*. Variation in synonymous evolutionary rates in the SARS-CoV-2 genome. Frontiers in Microbiology. 2023 Mar;14:1136386 【IF=4/JCR2区/中科院二区】
  11. Jing Tang#, Qiumei Xu#, Kang Tang, Xiaoyan Ye, Zicheng Cao, Min Zou, Jinfeng Zeng, Xinyan Guan, Jinglin Han, Yihan Wang, Lan Yang, Yishan Lin, Kaiao Jiang, Xiaoliang Chen, Yang Zhao, Dechao Tian, Chunwei Li, Wei Shen*, Xiangjun Du*. Susceptibility identification for seasonal influenza A/H3N2 based on baseline blood transcriptome. Frontiers in Immunology, 2023 Jan;13:1048774 【IF=5.7/JCR1区/中科院二区】
  12. Bing Zhang#, Weijuan Huang#, Sen Pei, Jinfeng Zeng, Wei Shen, Daoze Wang, Gang Wang, Tao Chen, Lei Yang, Peiwen Cheng, Dayan Wang*, Yuelong Shu*, Xiangjun Du*. Mechanisms for the circulation of influenza A(H3N2) in China: A spatiotemporal modelling study. PLoS Pathogen, 2022 Dec;18(12):e1011046 【IF=5.5/JCR1区/中科院一区】
  13. Bing Zhang#, Tao Chen#, Shiwen Liang, Wei Shen, Qianru Sun, Daoze Wang, Gang Wang, Jing Yang, Lei Yang, Dayan Wang*, Yuelong Shu*, Xiangjun Du*. Subtypes specified environmental dependence of seasonal influenza virus. Science of The Total Environment, 2022 Dec;852:158525 【IF=8.2/JCR1区/中科院一区】
  14. Kang Tang, Jing Tang, Jinfeng Zeng, Wei Shen, Min Zou, Chi Zhang, Qianru Sun, Xiaoyan Ye, Chunwei Li, Caijun Sun, Siyang Liu, Guozhi Jiang, Xiangjun Du*. A network view of human immune system and virus-human interaction. Frontiers in Immunology. 2022 Oct;13:997851 【IF=5.7/JCR1区/中科院二区】
  15. Hao Lei#, Lei Yang#, Gang Wang#, Chi Zhang#, Yuting Xin, Qianru Sun, Bing Zhang, Tao Chen, Jing Yang, Weijuan Huang, Modi Xu, Yu Xie, Yinghan Wang, Pei Xu, Litao Sun, Deyin Guo, Xiangjun Du*, Dayan Wang*, Yuelong Shu*, Transmission patterns of seasonal influenza in China between 2010 and 2018. Viruses, 2022 Sep;14(9):2063【IF=3.8/JCR2区/中科院三区】
  16. Zekai Qiu, Zicheng Cao, Min Zou, Kang Tang, Chi Zhang, Jing Tang, Jinfeng Zeng, Yaqi Wang, Qianru Sun, Daoze Wang, Xiangjun Du*. The effectiveness of governmental nonpharmaceutical interventions against COVID-19 at controlling seasonal influenza transmission: an ecological study. BMC Infectious Diseases, 2022 Apr;22(1):331 【IF=3.4/JCR2区/中科院三区】
  17. Zicheng Cao#, Zekai Qiu#, Feng Tang, Shiwen Liang, Yinghan Wang, Haoyu Long, Cai Chen, Bing Zhang, Chi Zhang, Yaqi Wang, Kang Tang, Jing Tang, Junhong Chen, Chunhui Yang, Yuzhe Xu, Yulin Yang, Shenglan Xiao, Dechao Tian, Guozhi Jiang, Xiangjun Du*. Drivers and forecasts of multiple waves of the coronavirus disease 2019 pandemic: a systematic analysis based on an interpretable machine learning framework. Transboundary and Emerging Diseases, 2022 Sep;69(5):e1584-e1594 【IF=3.5/JCR1区/中科院一区】
  18. Gang Wang, Bing Zhang, Shiwen Liang, Feng Tang, Yang Zhao, Dechao Tian, Xiangjun Du*. Exploring the interaction of influenza A subtypes based on an evolution-driven transmission model. Nonlinear Dynamics, 2022 Jun;110:933-944 【IF=5.2/JCR1区/中科院二区】
  19. Haoyu Long, Chi Zhang, Cai Chen, Jing Tang, Bing Zhang, Yinghan Wang, Jiali Pang, Wenzhe Su, Kuibiao Li, Biao Di, Yao-Qing Chen, Yuelong Shu and Xiangjun Du*. Assessment of the global circulation and endemicity of dengue. Transboundary and Emerging Diseases, 2022 Jun: 69(4):2148-2155 【IF=3.5/JCR1区/中科院一区】
  20. Yajuan Feng#, Kang Tang#, Qi Lai, Jingxian Liang, Min Feng, Zhong-Wei Zhou, Haissi Cui, Xiangjun Du, Han Zhang*, Litao Sun*. The Landscape of Aminoacyl-tRNA Synthetases Involved in Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Frontiers in Physiology, 2022 Jan;12:818297 【IF=3.2/JCR2区/中科院三区】
  21. Yaqi Wang, Guoqin Mai, Min Zou, Haoyu Long, Yao-Qing Chen, Litao Sun, Dechao Tian, Yang Zhao, Guozhi Jiang, Zicheng Cao*, Xiangjun Du*. Heavy chain sequence-based classifier for the specificity of human antibodies. Briefings in Bioinformatics, 2022 Jan;23(1):bbab516 【IF=6.8/JCR1区/中科院一区】
  22. Yinghan Wang#, Jinfeng Zeng#, Chi Zhang, Cai Chen, Zekai Qiu, Jiali Pang, Yutian Xu, Zhiqi Dong, Yanxin Song, Weiying Liu, Peipei Dong, Litao Sun, Yao-Qing Chen, Yuelong Shu*, Xiangjun Du*. New framework for recombination and adaptive evolution analysis with application to the novel coronavirus SARS-CoV-2. Briefings in Bioinformatics, 2021 Sep;22(5):bbab107 【IF=6.8/JCR1区/中科院一区】
  23. Bing Zhang#, Shiwen Liang#, Gang Wang, Chi Zhang, Cai Chen, Min Zou, Wei Shen, Haoyu Long, Daihai He, Yuelong Shu*, Xiangjun Du*. Synchronized nonpharmaceutical interventions for the control of COVID-19. Nonlinear Dynamics, 2021 May;106(2):1477-1489 【IF=5.2/JCR1区/中科院二区】
  24. Minchao Li#, Jinfeng Zeng#, Ruiting Li, Ziyu Wen, Yanhui Cai, Jeffrey Wallin, Yuelong Shu, Xiangjun Du*, Caijun Sun*. Rational design of a pan-coronavirus vaccine based on converved CTL epitopes. Viruses, 2021 Feb;13(2):333 【IF=3.8/JCR2区/中科院三区】
  25. Zicheng Cao#, Feng Tang#, Cai Chen, Chi Zhang, Yichen Guo, Ruizhen Lin, Zhihong Huang, Yi Teng, Ting Xie, Yutian Xu, Yanxin Song, Feng Wu, Peipei Dong, Ganfeng Luo, Yawen Jiang, Huachun Zou, Yao-Qing Chen, Litao Sun, Yuelong Shu, Xiangjun Du*. Impact of systematic factors on the outbreak outcome of novel coronavirus disease (COVID-19) in China. Journal of Medical Internet Research, 2020 Nov;22(11):e23853 【IF=5.8/JCR1区/中科院二区】
  26. Chi Zhang, Yinghan Wang, Cai Chen, Haoyu Long, Junbo Bai, Jinfeng Zeng, Zicheng Cao, Bing Zhang, Wei Shen, Feng Tang, Shiwen Liang, Caijun Sun, Yuelong Shu, Xiangjun Du*. A Mutation Network Method for Transmission Analysis of Human Influenza H3N2. Viruses, 2022 Oct;12(10):1125 【IF=3.8/JCR2区/中科院三区】
  27. Chi Zhang#, Cai Chen#, Wei Shen#, Feng Tang, Hao Lei, Yu Xie, Zicheng Cao, Kang Tang, Junbo Bai, Lehan Xiao, Yutian Xu, Yanxin Song, Jiwei Chen, Zhihui Guo, Yichen Guo, Xiao Wang, Modi Xu, Huachun Zou, Yuelong Shu*, Xiangjun Du*. Impact of population movement on the spread of 2019-nCoV in China. Emerging Microbes & Infection, 2020 Dec;9(1):988-990 【IF=8.4/JCR1区/中科院一区】
  28. Xiangjun Du#, Aaron A. King, Robert J. Woods, Mercedes Pascual*. Evolution-informed forecasting of seasonal influenza A (H3N2). Science Translational Medicine, 2017 Oct;9(413):eaan5325 【IF=15.8/JCR1区/中科院一区】
  29. Xiangjun Du#, E. Michael Gertz#, Damian Wojtowicz, Dina Zhabinskaya, David Levens, Craig Benham, Alejandro A. Schaffer*, and Teresa Przytycka*. Potential non-B DNA Regions in the Human Genome are Associated with Higher Rates of Nucleotide Mutation and Expression Variation. Nucleic Acids Research, 2014 Nov;42(20):12367-79 【IF=16.7/JCR1区/中科院二区】
  30. Xiangjun Du, Damian Wojtowicz, Albert A. Bowers, David L. Levens, Craig J. Benham and Teresa M. Przytycka*. The Genome-wide Distribution of Non-B DNA Motifs is Shaped by Operon Structure and Suggests the Transcriptional Importance of Non-B DNA Structures in Escherichia coli. Nucleic Acids Research, 2013 Jul;41(12):5965-77 【IF=16.7/JCR1区/中科院二区】
  31. Xiangjun Du, David J. Lipman and Joshua L. Cherry*. Why Does a Protein’s Evolutionary Rate Vary over Time? Genome Biology and Evolution, 2013;5:494-503 【IF=3.1/JCR2区/中科院二区】
  32. Xiangjun Du#, Libo Dong#, Yu Lan, Yousong Peng, Aiping Wu, Ye Zhang, Weijun Huang, Dayan Wang, Min Wang, Yuanji Guo, Yuelong Shu*, Taijiao Jiang*. Mapping of H3N2 Influenza Antigenic Evolution in China Reveals a Strategy for Vaccine Strain Recommendation. Nature Communications, 2012 Feb;3:709 【IF=14.7/JCR1区/中科院一区】
  33. Xiangjun Du#, Zhuo Wang#, Aiping Wu#, Lin Song, Yang Cao, Haiying Hang, Taijiao Jiang*. Networks of genomic co-occurrence capture characteristics of human influenza A (H3N2) evolution. Genome Research, 2008 Jan;18(1):178-187【IF=6.2/JCR1区/中科院一区】

 

发明专利

  1. 通过模型预测流感抗原的方法及应用，2012，发明专利，专利号：ZL201010147536.8；
  2. 一种基因突变网络的构建方法、装置、设备及存储介质，2023，发明专利，专利号：ZL 202110653805.6
  3. 流感易感标志物和基于该标志物的流感高危人群预测模型的构建方法与应用，2024，发明专利，专利号：ZL202310108655.X
  4. H9N2亚型禽流感毒株抗原性快速鉴别方法及装置，2024，发明专利，专利号：ZL202410020894.4
  5. 用于新冠病毒易感性的预测标志物以及预测方法、装置，2025，发明专利，专利号：ZL 202410950802.2
  6. 新型冠状病毒毒株抗原性快速鉴别方法及装置, 2025, 发明专利, 专利号：ZL 202410988849.8
  7. B型流感病毒抗原性快速鉴别方法、装置、终端及介质，2025，发明专利，专利号：ZL 202410989243.6

 

获奖情况

1.吴瑞奖学金，2009；

2.中华医学科技奖医学科学技术奖二等奖，流感防控的关键生物信息技术及其创新应用体系，2020；

 

研究生培养

已培养硕士研究生18名，博士研究生9名；正在培养博士研究生3名，硕士研究生6名。

 

招生信息

常年接收本科生进行科研培训，常年招收博士生及硕士生，常年招收博士后以及专职科研（研究员、副研究员）。欢迎对流行病与卫生统计学、生物信息学、计算与系统生物学、网络科学、人工智能、数学建模等方向感兴趣，特别对传染病计算系统生物学感兴趣的预防医学、生命科学、物理、数学以及计算机方向的博士后、研究生和本科生加入我们的研究团队！

联系人：杜向军，联系方式：duxj9@mail.sysu.edu.cn ，来信请注明申请方向及职位。